Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.56 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HPD | P32754 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 5/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20861040 | 0.91 | PIK3CA (0.53) | DDB1CRBNHSD11B1PIK3CAPRKDC | |
| SCHEMBL2986176 | 0.88 | DDB1 (0.54) | DDB1CRBNHSD11B1CYP3A4PIK3CA | |
| Hydrochloric Acid SCHEMBL2858713 | 0.87 | DDB1 (0.52) | DDB1CRBNHSD11B1CYP3A4PIK3CA | |
| SCHEMBL14186021 | 0.84 | DRD2 (0.57) | HSD11B1CYP3A4PIK3CASLC6A4DRD2 | |
| SCHEMBL31211853 | 0.84 | DDB1 (0.52) | DDB1CRBNHSD11B1CYP3A4PIK3CA | |
| SCHEMBL2636509 | 0.82 | DDB1 (0.51) | DDB1CRBNHSD11B1CYP3A4PIK3CA | |
| SCHEMBL2636510 | 0.82 | DDB1 (0.51) | DDB1CRBNHSD11B1CYP3A4PIK3CA | |
| SCHEMBL12893497 | 0.82 | HSD11B1 (0.50) | DDB1CRBNHSD11B1CYP3A4SLC6A4 | |
| SCHEMBL24405567 | 0.81 | DDB1 (0.50) | DDB1CRBNHSD11B1CYP3A4CTSS | |
| SCHEMBL11326674 | 0.81 | CTSS (0.48) | DDB1CRBNHSD11B1CYP3A4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |