Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674251 | 0.81 | PRKD3 (0.37) | NOTUMPRKD3CLK2DYRK1APRKD2 | |
| SCHEMBL20674052 | 0.76 | PDE2A (0.44) | BAZ2BSMN1; SMN2 | |
| SCHEMBL20674244 | 0.75 | CHRM1 (0.31) | BRD4CHRM1 | |
| SCHEMBL23937852 | 0.75 | BAZ2B (0.40) | HSD17B10BRD4CHRM1BAZ2B | |
| SCHEMBL28904493 | 0.74 | GAA (0.36) | NOTUMHRH4 | |
| SCHEMBL31514720 | 0.74 | GAA (0.36) | NOTUMHRH4 | |
| SCHEMBL18711826 | 0.72 | HRH4 (0.36) | NOTUMPRKD3CLK2DYRK1APRKD2 | |
| SCHEMBL23937743 | 0.72 | FTO (0.34) | NOTUMHTTSMN1; SMN2HRH4 | |
| SCHEMBL23937850 | 0.72 | BAZ2B (0.40) | HSD17B10BRD4BAZ2BHPGDTSHR | |
| SCHEMBL19341247 | 0.70 | HRH4 (0.51) | NOTUMPRKD3CLK2DYRK1APRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |