Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23937891 | 0.96 | KDM4E (0.33) | KDM5AKDM4EALDH1A1 | |
| SCHEMBL23937902 | 0.81 | PTGS1 (0.30) | — | |
| SCHEMBL20631706 | 0.80 | GAA (0.33) | — | |
| SCHEMBL23937920 | 0.79 | PTGS2 (0.32) | — | |
| SCHEMBL23937892 | 0.77 | PTGS2 (0.30) | — | |
| SCHEMBL23937898 | 0.75 | — | — | |
| SCHEMBL15730580 | 0.73 | L3MBTL1 (0.33) | KDM5AHSD17B10KDM4EALDH1A1CASP1 | |
| SCHEMBL23937901 | 0.69 | KDM4E (0.41) | HSD17B10KDM4EALDH1A1 | |
| SCHEMBL20631147 | 0.69 | LMNA (0.33) | MAPK1 | |
| SCHEMBL20631154 | 0.69 | KDM4E (0.35) | KDM5AHSD17B10KDM4EALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |