Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | FABP1 | P07148 | 1/20 | 0.67 |
| ▸ | FABP6 | P51161 | 1/20 | 0.67 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29580199 | 1.00 | KDM4E (0.69) | KDM4EFABP1FABP6CXCR4POLB | |
| SCHEMBL10054969 | 0.88 | FABP1 (0.79) | KDM4EFABP1FABP6CXCR4POLB | |
| SCHEMBL29580040 | 0.81 | KDM4E (1.00) | KDM4EFABP1FABP6CXCR4POLB | |
| SCHEMBL14980562 | 0.81 | KDM4E (1.00) | KDM4EFABP1FABP6CXCR4POLB | |
| SCHEMBL3956255 | 0.81 | ALDH1A1 (0.68) | KDM4EPOLBGRM4NPC1MAP4K4 | |
| SCHEMBL2230559 | 0.81 | FABP1 (1.00) | KDM4EFABP1FABP6CXCR4POLB | |
| SCHEMBL29664808 | 0.81 | FABP1 (1.00) | KDM4EFABP1FABP6CXCR4POLB | |
| SCHEMBL11573094 | 0.81 | FABP1 (0.67) | KDM4EFABP1FABP6CXCR4GAA | |
| SCHEMBL4718827 | 0.81 | FABP1 (0.67) | KDM4EFABP1FABP6CXCR4POLB | |
| SCHEMBL6301782 | 0.81 | FABP1 (0.67) | KDM4EFABP1FABP6CXCR4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | VALO HEALTH, INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | VALO EARLY DISCOVERY, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524966-B1 | Carboxamides as ubiquitin-specific protease inhibitors | USP28, USP25, USP24 | KDM4E 403/4885FABP1 3458/4885FABP6 3741/4885 |
| US-20210323975-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | USP28, USP25, USP24 | KDM4E 403/4885FABP1 3458/4885FABP6 3741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.