Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 4/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR2B | P41595 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18255841 | 0.84 | SLC6A4 (0.42) | SRD5A1KCNH2SLC6A4HRH3 | |
| SCHEMBL23938535 | 0.81 | HTR2A (0.41) | PNMTAADATSRD5A1HTR2ACHRNB2 | |
| SCHEMBL20013725 | 0.81 | KCNH2 (0.37) | CTSDSRD5A1KCNH2HTR2ACHRNB2 | |
| SCHEMBL18252819 | 0.81 | KCNH2 (0.44) | PNMTCTSDSRD5A1KCNH2HTR2A | |
| SCHEMBL18254951 | 0.71 | CHRNB2 (0.45) | PNMTHTR2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL12183955 | 0.70 | DPP7 (0.47) | PNMTCTSDAADATKCNH2ALDH1A1 | |
| SCHEMBL23938293 | 0.68 | SLC6A4 (0.43) | SRD5A1HTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL18255842 | 0.68 | SRD5A1 (0.42) | SRD5A1CHRNB2CHRNA4ALDH1A1SLC6A4 | |
| SCHEMBL18255846 | 0.68 | SRD5A1 (0.42) | SRD5A1CHRNB2CHRNA4ALDH1A1SLC6A4 | |
| SCHEMBL18254950 | 0.68 | SLC6A4 (0.44) | PNMTSRD5A1CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297438-B1 | CCR2 MODULATORS | CHEMOCENTRYX INC (US) | 2021-10-20 | — | — | EP | disclosed |