Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR3 | P49682 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21281559 | 0.71 | WDR5 (0.32) | AURKACDK1CCNB1CDK2AURKB | |
| SCHEMBL20459226 | 0.70 | CRBN (0.46) | CXCR3DDB1CRBN | |
| SCHEMBL21281367 | 0.70 | WDR5 (0.32) | AURKACDK1CCNB1CDK2AURKB | |
| SCHEMBL23939205 | 0.69 | CRBN (0.40) | CXCR3DDB1CRBNWDR5 | |
| SCHEMBL19310003 | 0.69 | CRBN (0.40) | CXCR3DDB1CRBNWDR5 | |
| SCHEMBL21281545 | 0.68 | CRBN (0.41) | CXCR3DDB1CRBNWDR5 | |
| SCHEMBL23938965 | 0.67 | CXCR3 (0.31) | CXCR3 | |
| SCHEMBL21927121 | 0.65 | CRBN (0.41) | CXCR3DDB1CRBNWDR5 | |
| SCHEMBL21281361 | 0.64 | — | — | |
| SCHEMBL21281325 | 0.63 | CRBN (0.46) | CXCR3DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-B1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2021-10-20 | — | — | EP | disclosed |