Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6405329 | 0.80 | CRBN (0.49) | PTGS2KDM4E | |
| SCHEMBL22775726 | 0.74 | CRBN (0.43) | PTGS2F10PIK3CDPIK3CAPIK3CG | |
| SCHEMBL6111335 | 0.73 | IDH1 (0.40) | KDM4E | |
| SCHEMBL29865430 | 0.73 | PTGS2 (0.52) | PTGS2F10PIK3CA | |
| SCHEMBL31205593 | 0.73 | PTGS2 (0.49) | PTGS2 | |
| SCHEMBL29865274 | 0.73 | PTGS2 (0.40) | PTGS2F10KDM4E | |
| SCHEMBL28685626 | 0.72 | L3MBTL1 (0.38) | PTGS2F10PIK3CDPIK3CAPIK3CG | |
| SCHEMBL198132 | 0.72 | PTGS2 (0.57) | PTGS2F10 | |
| SCHEMBL5740638 | 0.71 | PTGS2 (0.48) | PTGS2F10PIK3CA | |
| SCHEMBL20898722 | 0.70 | PTGS2 (0.36) | PTGS2F10PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3985001-A1 | PHARMACEUTICAL COMPOSITION USEFUL IN INHIBITING IDH1 | Les Laboratoires Servier SAS (FR) | 2022-04-20 | — | — | EP | disclosed |
| EP-3447052-B1 | METHODS OF PREPARING NEW IDH1 INHIBITORS | LES LABORATOIRES SERVIER SAS (FR) | 2021-10-20 | — | — | EP | disclosed |