SCHEMBL23944159

SCHEMBL23944159

C=CCN(c1c(-c2c(C)cc(C#N)cc2F)c(Cl)nc2ncnn12)[C@H](C(C)C)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN2 Q96KS0 7/20 0.39
PDE2A O00408 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23944462 0.91 EGLN2 (0.39) EGLN2PDE2A
SCHEMBL23943822 0.91 EGLN2 (0.40) EGLN2PDE2A
SCHEMBL23944153 0.87 EGLN2 (0.42) EGLN2PDE2A
SCHEMBL23943823 0.83 EGLN2 (0.31) EGLN2
SCHEMBL23943836 0.81
SCHEMBL22644287 0.80 KMT2A (0.33)
SCHEMBL22644286 0.80 KMT2A (0.33)
SCHEMBL23943838 0.80
SCHEMBL23944154 0.80 EGLN2 (0.45) EGLN2PDE2A
SCHEMBL23944460 0.79 ALDH1A1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021211408-A1 SUBSTITUTED {1,2,4,} TRIAZOLO{1,5-A} PYRIMIDINE COMPOUNDS AND USE IN STABILIZING MICROTUBULES THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2021-10-21 WO disclosed