Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239999 | 0.92 | KDM4E (0.42) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL3553083 | 0.85 | KDM4E (0.46) | ALDH1A1KDM4EKMT2AMEN1PSEN1 | |
| SCHEMBL3553079 | 0.85 | KDM4E (0.46) | ALDH1A1KDM4EKMT2AMEN1PSEN1 | |
| SCHEMBL5353392 | 0.79 | ABCC2 (0.43) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL5353398 | 0.79 | ABCC2 (0.43) | ALDH1A1KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL23945037 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL12355545 | 0.77 | MEN1 (0.48) | ALDH1A1KDM4EKMT2AMEN1TSHR | |
| SCHEMBL2240003 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KDM4EKMT2AMEN1PSEN1 | |
| SCHEMBL2240000 | 0.75 | ALDH1A1 (0.43) | ALDH1A1KDM4EKMT2AMEN1PSEN1 | |
| SCHEMBL5359096 | 0.75 | CCR2 (0.49) | ALDH1A1KDM4EKMT2AMAPTNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323976-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ARIAD PHARMACEUTICALS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323976-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ERBB2, EGFR, ERBB3 | ALDH1A1 4132/4885KDM4E 3455/4885APP 3287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.