⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23948322 | 0.88 | MELK (0.40) | — | |
| SCHEMBL23948328 | 0.84 | ABL1 (0.38) | — | |
| SCHEMBL23947980 | 0.84 | HCAR1 (0.35) | — | |
| SCHEMBL23948323 | 0.82 | MAPK1 (0.38) | — | |
| SCHEMBL23948320 | 0.82 | EGLN1 (0.32) | — | |
| SCHEMBL23947981 | 0.82 | KDR (0.37) | — | |
| SCHEMBL26306173 | 0.81 | ADORA3 (0.33) | — | |
| SCHEMBL26308858 | 0.81 | JAK2 (0.34) | — | |
| SCHEMBL23948325 | 0.81 | FLT3 (0.34) | — | |
| SCHEMBL26306206 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242536-A1 | METHODS FOR PREPARING TYROSINE RECEPTOR KINASE INHIBITORS | PYRAMID BIOSCIENCES, INC. | 2023-08-03 | — | — | US | disclosed |
| WO-2021211882-A1 | METHODS FOR PREPARING TYROSINE RECEPTOR KINASE INHIBITORS | PYRAMID BIOSCIENCES, INC. (US) | 2021-10-21 | — | — | WO | disclosed |