Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL6732479 | 0.97 | ALDH1A1 (0.50) | ALDH1A1PDK1PDK2PDK3 | |
| Tetrahydrofuran SCHEMBL40243 | 0.89 | — | — | |
| Tetrahydrofuran SCHEMBL9077806 | 0.89 | ALDH1A1 (0.67) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL10606207 | 0.88 | ALDH1A1 (0.47) | ALDH1A1TSHR | |
| Cyclohexane SCHEMBL1742381 | 0.86 | ALDH1A1 (0.61) | ALDH1A1TTRTSHR | |
| Methylene Chloride SCHEMBL537651 | 0.86 | ALDH1A1 (0.61) | ALDH1A1TTRTSHR | |
| Tetrahydrofuran SCHEMBL6848959 | 0.86 | — | — | |
| Methylene Chloride SCHEMBL27973738 | 0.86 | — | — | |
| Tetrahydrofuran SCHEMBL1708038 | 0.86 | ALDH1A1 (0.73) | ALDH1A1TTRTSHRPDK1PDK2 | |
| Tetrahydrofuran SCHEMBL49157 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558900-A | A kind of derivative of nagilactone J and preparation method thereof and the application in mesenchymal stem cell culture | 吾建峰 | 2018-09-21 | — | — | CN | claimed |
| CN-108530461-A | A kind of derivative of nagilactone J and preparation method thereof and the purposes for promoting mesenchymal stem cells differentiation | 吾建峰 | 2018-09-14 | — | — | CN | claimed |
| WO-2023088493-A1 | FURO-PYRIDONE COMPOUND AND USE THEREOF | 中国科学院广州生物医药与健康研究院 | 2023-05-25 | — | — | WO | disclosed |
| CN-108558900-A | A kind of derivative of nagilactone J and preparation method thereof and the application in mesenchymal stem cell culture | 吾建峰 | 2018-09-21 | — | — | CN | disclosed |
| CN-108530461-A | A kind of derivative of nagilactone J and preparation method thereof and the purposes for promoting mesenchymal stem cells differentiation | 吾建峰 | 2018-09-14 | — | — | CN | disclosed |
| US-8697692-B2 | Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2014-04-15 | — | — | US | disclosed |
| US-8362251-B2 | Pyrrolo [3,2-C] pyridine-4-one 2-indolinone protein kinase inhibitors | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2013-01-29 | — | — | US | disclosed |
| US-20110301353-A1 | PYRROLO [3,2-C] PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2011-12-08 | — | — | US | disclosed |
| US-8012966-B2 | Pyrrolo [3,2-c] pyridine-4-one 2-indolinone protein kinase inhibitors | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2011-09-06 | — | — | US | disclosed |
| CN-101039946-B | Disubstituted pyrazolobenzodiazepines useful as inhibitors for CDK2 and angiogenesis and for the treatment of breast, colon, lung and prostate cancer | HOFFMANN LA ROCHE | 2010-12-08 | — | — | CN | disclosed |
| CN-101899049-A | Disubstituted pyrazole and benzodiazepines class | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |
| US-20100004239-A1 | Pyrrolo [3,2-C] Pyridine-4-One 2-Indolinone Protein Kinase Inhibitors | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2010-01-07 | — | — | US | disclosed |
| US-7524840-B2 | 7,8-disubstituted pyrazolobenzodiazepines | HOFFMANN-LA ROCHE INC. (US) | 2009-04-28 | — | — | US | disclosed |
| EP-1802625-B1 | DISUBSTITUTED PYRAZOLOBENZODIAZEPINES USEFUL AS INHIBITORS FOR CDK2 AND ANGIOGESIS, AND FOR THE TREATMENT OF BREAST, COLON, LUNG AND PROSTATE CANCER | HOFFMANN LA ROCHE (CH) | 2008-06-18 | — | — | EP | disclosed |
| CN-101039946-A | Disubstituted pyrazolobenzodiazepines * useful as inhibitors for CDK2 and angiogenesis and for the treatment of breast, colon, lung and prostate cancer | HOFFMANN LA ROCHE (CH) | 2007-09-19 | — | — | CN | disclosed |
| EP-1802625-A1 | DISUBSTITUTED PYRAZOLOBENZODIAZEPINES USEFUL AS INHIBITORS FOR CDK2 AND ANGIOGESIS, AND FOR THE TREATMENT OF BREAST, COLON, LUNG AND PROSTATE CANCER | F. Hoffmann-Roche AG (CH) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006040036-A1 | DISUBSTITUTED PYRAZOLOBENZODIAZEPINES USEFUL AS INHIBITORS FOR CDK2 AND ANGIOGESIS, AND FOR THE TREATMENT OF BREAST, COLON, LUNG AND PROSTATE CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | disclosed |
| US-20060079511-A1 | 7,8-Disubstituted pyrazolobenzodiazepines | LIU JIN-JUN | 2006-04-13 | — | — | US | disclosed |
| US-5668271-A | Indolopyrrolocarbazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| US-5135839-A | Coupler mixture | EASTMAN KODAK COMPANY (US) | 1992-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301353-A1 | PYRROLO [3,2-C] PYRIDINE-4-ONE 2-INDOLINONE PROTEIN KINASE INHIBITORS | DMPK, PDPK1, PRKAR2A | ALDH1A1 3032/4885TTR 4667/4885TSHR 1260/4885 |
| US-20060079511-A1 | 7,8-Disubstituted pyrazolobenzodiazepines | CDK2, CDK1, CDK7 | ALDH1A1 2432/4885TTR 4866/4885TSHR 1618/4885 |
| US-20100004239-A1 | Pyrrolo [3,2-C] Pyridine-4-One 2-Indolinone Protein Kinase Inhibitors | DMPK, CDK2, PRKAR2A | ALDH1A1 2899/4885TTR 4577/4885TSHR 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.