Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.48 |
| ▸ | HTR2A | P28223 | 8/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 9/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1690952 | 0.85 | HTR2A (0.50) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| SCHEMBL20612461 | 0.83 | DRD2 (0.53) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| SCHEMBL6025550 | 0.76 | PKM (0.48) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| SCHEMBL30529385 | 0.75 | HTR2C (0.49) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| SCHEMBL3859304 | 0.75 | HTR2C (0.49) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| SCHEMBL23928891 | 0.75 | SIGMAR1 (0.50) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| SCHEMBL19030580 | 0.75 | HTR2C (0.39) | DRD2HTR2AHTR2CHTR2B | |
| Bromide SCHEMBL5772502 | 0.74 | HTR2C (0.48) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| Hydrochloric Acid SCHEMBL4214755 | 0.74 | HTR2C (0.48) | DRD2HTR2AEPHX2HTR2CTRPM8 | |
| SCHEMBL15075094 | 0.73 | EPHX2 (0.43) | DRD2HTR2AEPHX2HTR2CTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | CHRNA7, CHRM3, ADRB3 | DRD2 262/4885HTR2A 398/4885EPHX2 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.