Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ACLY | P53396 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395836 | 0.88 | MKNK1 (0.43) | LMNANPSR1TSHRUSP2MAPK1 | |
| SCHEMBL1155160 | 0.64 | ALDH1A1 (0.60) | LMNAIKBKBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30070521 | 0.64 | ALDH1A1 (0.60) | LMNAIKBKBALDH1A1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL21412299 | 0.63 | ALDH1A1 (0.58) | LMNAIKBKBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL27802325 | 0.61 | CYP2A6 (0.64) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4248367 | 0.61 | CYP2A6 (0.51) | LMNAALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL18528875 | 0.60 | CYP2A6 (0.52) | LMNAIKBKBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL28592192 | 0.59 | MKNK1 (0.58) | IKBKBALDH1A1CYP1A2CYP3A4MKNK1 | |
| SCHEMBL4248368 | 0.59 | CYP2A6 (0.50) | LMNAIKBKBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL29266806 | 0.59 | CYP2A6 (0.54) | LMNATSHRALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017775-B2 | 1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20090326009-A1 | Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity | Santen Pharmaceutical Co., (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326009-A1 | Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity | NR3C1, NR3C2, NR5A1 | LMNA 4519/4885IKBKB 1270/4885NPSR1 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.