Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | ICMT | O60725 | 1/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23959169 | 0.75 | NPSR1 (0.45) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL16741512 | 0.65 | SMN1; SMN2 (0.50) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL9125344 | 0.65 | HPGD (0.62) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL10587847 | 0.65 | ALDH1A1 (0.83) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL12835586 | 0.64 | HPGD (0.57) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL11923444 | 0.64 | SMN1; SMN2 (0.69) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL2752779 | 0.63 | SMN1; SMN2 (0.69) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL24856036 | 0.63 | SMN1; SMN2 (0.62) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL23135469 | 0.63 | NPSR1 (0.65) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 | |
| SCHEMBL2625524 | 0.62 | SMN1; SMN2 (0.55) | SMN1; SMN2HPGDALDH1A1NPSR1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216828-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-10-28 | — | — | WO | disclosed |