Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23959178 | 0.77 | — | — | |
| SCHEMBL23959152 | 0.75 | SMN1; SMN2 (0.43) | NPSR1SMN1; SMN2HPGDEPHX1KMT2A | |
| SCHEMBL2625524 | 0.75 | SMN1; SMN2 (0.55) | NPSR1HSD11B1SMN1; SMN2HPGDEPHX1 | |
| SCHEMBL5327904 | 0.74 | ALDH1A1 (0.56) | NPSR1HSD11B1SMN1; SMN2HPGDEPHX1 | |
| SCHEMBL10132087 | 0.74 | HSD11B1 (0.69) | NPSR1HSD11B1SMN1; SMN2HPGDEPHX1 | |
| SCHEMBL12572628 | 0.73 | SMN1; SMN2 (0.53) | NPSR1HSD11B1SMN1; SMN2HPGDEPHX1 | |
| SCHEMBL9124247 | 0.73 | HPGD (0.56) | NPSR1SMN1; SMN2HPGDEPHX1KMT2A | |
| SCHEMBL14986340 | 0.72 | EPHX1 (0.51) | NPSR1SMN1; SMN2EPHX1ALDH1A1EPHX2 | |
| SCHEMBL14748208 | 0.72 | HPGD (0.55) | NPSR1SMN1; SMN2HPGDEPHX1KMT2A | |
| SCHEMBL11570602 | 0.71 | NPSR1 (0.59) | NPSR1SMN1; SMN2HPGDEPHX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216828-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-10-28 | — | — | WO | disclosed |