Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.42 |
| ▸ | PIK3R5 | Q8WYR1 | 3/20 | 0.42 |
| ▸ | PIK3R3 | Q92569 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23959556 | 0.93 | KMT2A (0.44) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL21752495 | 0.93 | KMT2A (0.51) | KMT2AKCNH2MCHR1SCDALOX15 | |
| SCHEMBL23959626 | 0.92 | KMT2A (0.43) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL23959539 | 0.91 | KDM4E (0.41) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL23959580 | 0.91 | CNR1 (0.42) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL23959578 | 0.91 | MLNR (0.43) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL23959560 | 0.90 | LIPE (0.43) | KMT2AALOX15KDM4ESMN1; SMN2CNR1 | |
| SCHEMBL23959703 | 0.89 | ALOX15 (0.42) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL23959602 | 0.88 | KMT2A (0.40) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB | |
| SCHEMBL23959622 | 0.88 | ALOX15 (0.39) | KMT2APIK3CDPIK3R2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210330676-A1 | NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210330676-A1 | NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | IDO1, IDO2, KYNU | KMT2A 1461/4885PIK3CD 1908/4885PIK3R2 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.