Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23959352 | 1.00 | TSHR (0.37) | TSHRMEN1KMT2ATP53THRB | |
| SCHEMBL23959350 | 0.98 | TSHR (0.36) | TSHRMEN1KMT2ATP53THRB | |
| SCHEMBL23961062 | 0.98 | TSHR (0.36) | TSHRMEN1KMT2ATP53THRB | |
| SCHEMBL23961061 | 0.86 | LMNA (0.39) | TP53THRBPOLBPDE4BPDE4D | |
| SCHEMBL26375007 | 0.83 | MEN1 (0.39) | TSHRMEN1KMT2ATP53THRB | |
| SCHEMBL23930423 | 0.77 | KMT2A (0.47) | TSHRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL23930440 | 0.74 | KMT2A (0.45) | TSHRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL23961084 | 0.74 | KMT2A (0.45) | TSHRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL25567604 | 0.74 | KMT2A (0.45) | TSHRMEN1KMT2AALDH1A1POLB | |
| SCHEMBL24174030 | 0.67 | FAAH (0.35) | TSHRMEN1KMT2APDE4BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021214470-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | C4X DISCOVERY LIMITED (GB) | 2021-10-28 | — | — | WO | disclosed |