SCHEMBL23964309

SCHEMBL23964309

c1ccc2[nH]c(CN3CCN(c4nccc5ccccc45)CC3)cc2c1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 2/20 0.57
HTR2C P28335 1/20 0.53
DRD2 P14416 6/20 0.51
DRD3 P35462 6/20 0.51
DRD4 P21917 4/20 0.51
HTR1A P08908 2/20 0.51
ADRA2A P08913 1/20 0.51
ADRA2B P18089 1/20 0.51
ADRA2C P18825 1/20 0.51
OPRK1 P41145 1/20 0.51
SORD Q00796 2/20 0.48
CCR8 P51685 1/20 0.46
HTR1D P28221 1/20 0.45
HTR1B P28222 1/20 0.45
SLC6A4 P31645 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30041280 1.00 HRH4 (0.57) HRH4HTR2CDRD2DRD3DRD4
SCHEMBL23964310 0.85 HRH4 (0.55) HRH4HTR2CDRD2DRD3DRD4
SCHEMBL30297589 0.85 HRH4 (0.55) HRH4HTR2CDRD2DRD3DRD4
SCHEMBL30041015 0.82 HRH4 (0.60) HRH4DRD2DRD3DRD4HTR1A
SCHEMBL23964254 0.82 HRH4 (0.60) HRH4DRD2DRD3DRD4HTR1A
SCHEMBL23964193 0.81 HRH4 (0.55) HRH4DRD2DRD3DRD4HTR1A
SCHEMBL6782457 0.80 HRH4 (0.63) HRH4HTR2CDRD2DRD3DRD4
SCHEMBL6782266 0.80 HRH4 (0.56) HRH4DRD2DRD3HTR1A
SCHEMBL23964182 0.80 HSD11B1 (0.63) HRH4DRD2DRD3DRD4HTR1A
SCHEMBL30041209 0.80 HSD11B1 (0.63) HRH4DRD2DRD3DRD4HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2023-05-18 US disclosed
CN-115427404-A Collagen 1 translation inhibitors and methods of use thereof 艾尼莫生物科技公司 2022-12-02 CN disclosed
WO-2021216665-A9 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-12-02 WO disclosed
WO-2021216665-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF ANIMA BIOTECH INC. (US) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150980-A1 COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF COL1A1, COL2A1, COL14A1 HRH4 4471/4885HTR2C 4659/4885DRD2 4780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.