Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19399180 | 0.81 | CHRNA7 (0.60) | CHRNA7KDM4ESMN1; SMN2TRPM8HSD17B1 | |
| SCHEMBL19398586 | 0.77 | CHRNA7 (0.55) | CHRNA7KDM4ESMN1; SMN2TRPM8HSD17B1 | |
| SCHEMBL19831817 | 0.73 | CHRNA7 (0.52) | CHRNA7KDM4ESMN1; SMN2TRPM8MAPT | |
| SCHEMBL19378302 | 0.71 | CHRNA7 (1.00) | CHRNA7KDM4EMAPT | |
| SCHEMBL4607588 | 0.71 | KDM4E (0.43) | CHRNA7KDM4ESMN1; SMN2TRPM8HSD17B1 | |
| SCHEMBL27436265 | 0.71 | RAB9A (0.43) | CHRNA7KDM4ESMN1; SMN2PDE4BMAPT | |
| SCHEMBL4606885 | 0.70 | CHRNA7 (0.48) | CHRNA7KDM4ESMN1; SMN2TRPM8 | |
| SCHEMBL19195986 | 0.68 | HSD17B1 (0.54) | SMN1; SMN2HSD17B1HSD17B2MAPT | |
| SCHEMBL19399148 | 0.67 | KDM4E (0.60) | KDM4ESMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL13801078 | 0.66 | ADORA3 (0.56) | KDM4ESMN1; SMN2TRPM8MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3433234-B1 | ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | MERCK SHARP & DOHME (US) | 2021-10-27 | — | — | EP | disclosed |