Sugi Predict

Sugi Predict / Compounds / 3,7-Dihydroxyflavone

3,7-Dihydroxyflavone

3,7-Dihydroxyflavone

SCHEMBL2396684

O=c1c(O)c(-c2ccccc2)oc2cc(O)ccc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 10/20 1.00
▸ MEN1 O00255 10/20 1.00
▸ KMT2A Q03164 10/20 1.00
▸ KDM4E B2RXH2 9/20 1.00
▸ MAPT P10636 8/20 1.00
▸ HSD17B10 Q99714 7/20 1.00
▸ ALOX15 P16050 5/20 1.00
▸ CASP1 P29466 4/20 1.00
▸ CASP7 P55210 4/20 1.00
▸ ALDH1A1 P00352 7/20 0.82
▸ CYP2C9 P11712 6/20 0.82
▸ MAPK1 P28482 5/20 0.82
▸ HPGD P15428 5/20 0.82
▸ CYP2C19 P33261 4/20 0.82
▸ TP53 P04637 4/20 0.82
▸ CYP2D6 P10635 3/20 0.82
▸ TDP1 Q9NUW8 2/20 0.74
▸ TSHR P16473 1/20 0.74
▸ RECQL P46063 2/20 0.73
▸ CD38 P28907 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
3,7-Dihydroxyflavone SCHEMBL29625323 1.00 CYP3A4 (1.00) CYP3A4MEN1KMT2AKDM4EMAPT
Resokaempferol SCHEMBL344710 0.90 MEN1 (1.00) CYP3A4MEN1KMT2AKDM4EMAPT
Resokaempferol SCHEMBL30873045 0.90 MEN1 (1.00) CYP3A4MEN1KMT2AKDM4EMAPT
SCHEMBL31675772 0.89 MEN1 (0.81) CYP3A4MEN1KMT2AKDM4EMAPT
SCHEMBL344155 0.89 MEN1 (0.81) CYP3A4MEN1KMT2AKDM4EMAPT
SCHEMBL1627936 0.88 CYP3A4 (0.82) CYP3A4MEN1KMT2AKDM4EMAPT
SCHEMBL15456750 0.88 CYP3A4 (0.82) CYP3A4MEN1KMT2AKDM4EMAPT
Fisetin SCHEMBL4887417 0.87 MEN1 (0.81) CYP3A4MEN1KMT2AKDM4EMAPT
Resokaempferol SCHEMBL4728192 0.87 MEN1 (0.82) CYP3A4MEN1KMT2AKDM4EMAPT
SCHEMBL7948035 0.86 MEN1 (0.76) CYP3A4MEN1KMT2AKDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 — — CN claimed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 — — CN claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 — — CN claimed
US-20250161459-A1 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2025-05-22 — — US claimed
WO-2025038970-A1 MODIFIED OLIGONUCLEOTIDES CONTAINING MULTIPLE OLIGONUCLEOTIDES ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 — — WO claimed
WO-2025038963-A1 OLIGONUCLEOTIDES CONTAINING MULTIPLE LIGANDS AND/OR LIPIDS ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 — — WO claimed
WO-2025038971-A1 OLIGONUCLEOTIDES CONTAINING A LIGAND AT A NUCLEOBASE, 2' POSITION, OR 3' POSITION ADARX PHARMACEUTICALS, INC. (US) 2025-02-20 — — WO claimed
EP-4475837-A2 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF Adarx Pharmaceuticals, Inc. (US) 2024-12-18 — — EP claimed
CN-118973616-A Trkb ligand conjugated compounds and uses thereof 阿达尔克斯制药有限公司 2024-11-15 — — CN claimed
CN-117618647-A Anti-infection bone repair promoting preparation for sequentially regulating and controlling macrophage immune microenvironment and preparation method thereof 广东省科学院微生物研究所(广东省微生物分析检测中心) 2024-03-01 — — CN claimed
US-20130040947-A1 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2013-02-14 — — US claimed
WO-2011156479-A9 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2012-05-31 — — WO claimed
WO-2011156479-A2 TRKB AGONISTS AND METHODS OF USE EMORY UNIVERSITY (US) 2011-12-15 — — WO claimed
WO-2008141074-A1 IDENTIFICATION OF COMPOUNDS THAT PROTECT AGAINST AMYLOID DISEASES SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2008-11-20 — — WO claimed
US-20070160688-A1 Use of flavonoids to increase blood serum levels of dehydroepiandrosterone PROPRIETARY WELLNESS, LLC 2007-07-12 — — US claimed
US-6872771-B1 Tire with rubber containing flavone THE GOODYEAR TIRE & RUBBER COMPANY (US) 2005-03-29 — — US claimed
JP-2003504327-A — — 2003-02-04 — — JP claimed
EP-1223928-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS Prendergast, Patrick Thomas (IE) 2002-07-24 — — EP claimed
WO-2001080855-A1 TELOMERASE INHIBITORS AND METHODS OF THEIR USE GERON CORPORATION (US) 2001-11-01 — — WO claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130040947-A1 TRKB AGONISTS AND METHODS OF USE NTRK2, BDNF, NTRK1 CYP3A4 1228/4885MEN1 4679/4885KMT2A 1050/4885
US-20250161459-A1 TRKB LIGAND CONJUGATED COMPOUNDS AND USES THEREOF NTRK2, NTRK1, BDNF CYP3A4 4808/4885MEN1 4051/4885KMT2A 1269/4885
US-20070160688-A1 Use of flavonoids to increase blood serum levels of dehydroepiandrosterone SHBG, CYP17A1, HSD17B11 CYP3A4 153/4885MEN1 2514/4885KMT2A 4211/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.