Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DTYMK | P23919 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | GPR4 | P46093 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23915630 | 0.90 | MAPT (0.54) | ALOX15NPC1LMNANR2F2HTT | |
| SCHEMBL23914917 | 0.88 | NPC1 (0.54) | NPC1LMNANR2F2HTTSMN1; SMN2 | |
| SCHEMBL30976451 | 0.75 | L3MBTL1 (0.56) | NPC1LMNANR2F2HTTSMN1; SMN2 | |
| SCHEMBL23966581 | 0.75 | SLC6A4 (0.46) | LMNASMN1; SMN2SLC6A4HTR2AHTR2C | |
| SCHEMBL27989756 | 0.74 | CHRM2 (0.52) | DTYMKCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL23913676 | 0.73 | MAPT (0.53) | ALOX15NPC1LMNANR2F2HTT | |
| SCHEMBL8242595 | 0.72 | USP2 (0.61) | NPC1LMNAHTTSMN1; SMN2CHRM2 | |
| SCHEMBL578012 | 0.72 | KMT2A (0.57) | LMNAHTTDTYMKCHRM2CHRM4 | |
| SCHEMBL29659287 | 0.72 | KMT2A (0.57) | LMNAHTTDTYMKCHRM2CHRM4 | |
| SCHEMBL30976347 | 0.71 | MEN1 (0.69) | NPC1LMNANR2F2HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |