Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.59 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.59 |
| ▸ | AR | P10275 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12266094 | 0.90 | ALDH1A1 (0.63) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL4504207 | 0.89 | ABCG2 (0.58) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL5685501 | 0.88 | ABCG2 (0.57) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL2396107 | 0.85 | ABCG2 (0.64) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL2396323 | 0.84 | HSD17B10 (0.66) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| Flavonol SCHEMBL16150505 | 0.79 | KDM4E (0.88) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL9531458 | 0.79 | ALDH1A1 (0.76) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL2397588 | 0.79 | ABCG2 (0.56) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL29993383 | 0.78 | ABCG2 (1.00) | ABCG2ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL253523 | 0.78 | ABCG2 (1.00) | ABCG2ALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856085-B1 | FLAVONOID COMPOUNDS AND USES THEREOF | HOWARD FLOREY INST PTY LTD (AU) | 2015-07-08 | — | — | EP | disclosed |
| EP-1856085-B1 | FLAVONOID COMPOUNDS AND USES THEREOF | HOWARD FLOREY INST PTY LTD (AU) | 2015-07-08 | — | — | EP | disclosed |
| CN-101137639-B | Flavonoid compounds and uses thereof | FLOREY HOWARD INST | 2012-05-23 | — | — | CN | disclosed |
| US-8017649-B2 | Flavonoid compounds and uses thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2011-09-13 | — | — | US | disclosed |
| US-8017649-B2 | Flavonoid compounds and uses thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2011-09-13 | — | — | US | disclosed |
| US-8017649-B2 | Flavonoid compounds and uses thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2011-09-13 | — | — | US | disclosed |
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2009-05-21 | — | — | US | disclosed |
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2009-05-21 | — | — | US | disclosed |
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2009-05-21 | — | — | US | disclosed |
| CN-101137639-A | Flavonoid compounds and uses thereof | AND MEDICINE HOWARD FLOREY INS (AU) | 2008-03-05 | — | — | CN | disclosed |
| EP-1856085-A1 | FLAVONOID COMPOUNDS AND USES THEREOF | Howard Florey Institute of Experimental Physiology and Medicine (AU) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094357-A1 | FLAVONOID COMPOUNDS AND USES THEREOF | HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) | 2006-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090130051-A1 | Flavonoid Compounds and Uses Thereof | CAT, NQO1, GPX4 | ABCG2 102/4885ALDH1A1 609/4885KDM4E 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.