Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 10/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 10/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.47 |
| ▸ | PRCP | P42785 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23967690 | 0.97 | PRKAG1 (0.46) | PRKAG1PRKAB1PRKAA2PRKAA1PRCP | |
| SCHEMBL16069390 | 0.85 | PRKAG1 (0.46) | PRKAG1PRKAB1PRKAA2PRKAA1PRCP | |
| SCHEMBL16069385 | 0.82 | PRKAG1 (0.45) | PRKAG1PRKAB1PRKAA2PRKAA1PRCP | |
| SCHEMBL23967839 | 0.81 | PRKAG1 (0.48) | PRKAG1PRKAB1PRKAA2PRKAA1S1PR1 | |
| SCHEMBL23967847 | 0.78 | PRKAG1 (0.47) | PRKAG1PRKAB1PRKAA2PRKAA1S1PR1 | |
| SCHEMBL16069386 | 0.73 | SCD (0.41) | PRKAG1PRKAB1PRKAA2 | |
| SCHEMBL16069513 | 0.73 | SCD (0.39) | PRKAG1PRKAB1PRKAA2KDM4E | |
| SCHEMBL16069387 | 0.72 | SCD (0.41) | PRKAG1PRKAB1PRKAA2 | |
| SCHEMBL23967724 | 0.72 | KDM4E (0.37) | PRKAG1PRKAB1PRKAA2PRKAA1KDM4E | |
| SCHEMBL17402629 | 0.72 | PTGS1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |