Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAG1 | P54619 | 8/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 8/20 | 0.47 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 8/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23967839 | 0.97 | PRKAG1 (0.48) | PRKAG1PRKAB1PRKAA2S1PR1PRKAA1 | |
| SCHEMBL16069441 | 0.84 | PRKAG1 (0.47) | PRKAG1PRKAB1PRKAA2S1PR1FFAR1 | |
| SCHEMBL23967690 | 0.82 | PRKAG1 (0.46) | PRKAG1PRKAB1PRKAA2S1PR1PRKAA1 | |
| SCHEMBL16069331 | 0.81 | PRKAG1 (0.47) | PRKAG1PRKAB1PRKAA2S1PR1FFAR1 | |
| SCHEMBL23967843 | 0.78 | PRKAG1 (0.47) | PRKAG1PRKAB1PRKAA2S1PR1PRKAA1 | |
| SCHEMBL23967677 | 0.73 | PRKAG1 (0.51) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL16069373 | 0.73 | PTGS2 (0.40) | PRKAG1PRKAB1PRKAA2PRKAA1PRKAB2 | |
| SCHEMBL1121937 | 0.73 | PRKAG1 (0.43) | PRKAG1PRKAB1PRKAA2S1PR1PRKAA1 | |
| SCHEMBL1122056 | 0.70 | GPR17 (0.48) | FFAR1GPR17 | |
| SCHEMBL10593440 | 0.70 | SIRT1 (0.56) | S1PR1FFAR1GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |