Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 6/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23968199 | 0.85 | MAPKAPK2 (0.57) | MELKMAPKAPK2TGFBR1MEN1KMT2A | |
| SCHEMBL23968136 | 0.81 | MKNK1 (0.47) | MELKMAPKAPK2TGFBR1ACVR1 | |
| SCHEMBL23968106 | 0.80 | MELK (0.43) | MELK | |
| SCHEMBL23968101 | 0.79 | DRD2 (0.43) | MELKMAPKAPK2MTORMEN1KMT2A | |
| SCHEMBL23968001 | 0.78 | MELK (0.51) | MELK | |
| SCHEMBL23968093 | 0.78 | MAP4K4 (0.54) | MELK | |
| SCHEMBL23968168 | 0.76 | MELK (0.46) | MELKMAPKAPK2 | |
| SCHEMBL23968090 | 0.76 | MELK (0.49) | MELKMAPKAPK2 | |
| SCHEMBL23968098 | 0.75 | MELK (0.48) | MELKRET | |
| SCHEMBL23968072 | 0.75 | MELK (0.45) | MELKMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104705-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |