Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8160698 | 0.84 | HSD11B1 (0.66) | HTR2BHSD11B1SLC6A7MEN1KMT2A | |
| SCHEMBL23968059 | 0.82 | SLC6A7 (0.50) | HSD11B1SLC6A7MEN1KMT2APTPN1 | |
| SCHEMBL30967272 | 0.80 | HSD11B1 (0.71) | HSD11B1MEN1KMT2APTPN1KDM4E | |
| SCHEMBL23967996 | 0.78 | MEN1 (0.43) | HTR2BSLC6A7MEN1KMT2AMAP4K4 | |
| SCHEMBL180639 | 0.78 | BCL2L1 (0.59) | HSD11B1MEN1KMT2AMAP4K4ALDH1A1 | |
| SCHEMBL8155644 | 0.75 | HSD11B1 (0.54) | HTR2BHSD11B1SLC6A7MEN1KMT2A | |
| SCHEMBL24018950 | 0.73 | HTR2B (0.51) | HTR2BHSD11B1SLC6A7MEN1KMT2A | |
| SCHEMBL3641180 | 0.72 | GRM5 (0.76) | HSD11B1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL13952174 | 0.72 | HSD11B1 (0.57) | HSD11B1SLC6A7MEN1KMT2APTPN1 | |
| SCHEMBL21472163 | 0.72 | GRM5 (0.57) | HSD11B1MEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104705-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |