Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21170645 | 0.82 | HRH3 (0.54) | MEN1KMT2ARAB9ALMNATACR3 | |
| SCHEMBL23968111 | 0.78 | HTR2B (0.51) | MEN1KMT2ASLC6A7MAP4K4MAPKAPK2 | |
| SCHEMBL23968059 | 0.77 | SLC6A7 (0.50) | MEN1KMT2ASLC6A7MAP4K4LMNA | |
| SCHEMBL24018903 | 0.75 | KMT2A (0.46) | MEN1KMT2ARAB9ASLC6A7TACR3 | |
| SCHEMBL180639 | 0.74 | BCL2L1 (0.59) | MEN1KMT2ARAB9AMAP4K4MAPKAPK2 | |
| SCHEMBL25205366 | 0.70 | PTGDR2 (0.44) | MEN1KMT2ARAB9A | |
| SCHEMBL12093445 | 0.69 | PKM (0.67) | MEN1KMT2ARAB9ALMNATACR3 | |
| SCHEMBL4751256 | 0.69 | HSP90AA1 (0.55) | KMT2ARAB9AHRH3SMN1; SMN2 | |
| SCHEMBL14117676 | 0.69 | HRH3 (0.54) | MEN1KMT2ARAB9AHRH3JAK2 | |
| SCHEMBL623354 | 0.69 | POLB (0.57) | MEN1KMT2ARAB9ALMNAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104705-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |