Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 12/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23968144 | 0.87 | MELK (0.37) | MELKRETGAAMAPTHSD17B10 | |
| SCHEMBL23968021 | 0.87 | MELK (0.37) | MELKRET | |
| SCHEMBL23968184 | 0.84 | MELK (0.39) | MELKRET | |
| SCHEMBL23968097 | 0.83 | MELK (0.39) | MELKRETHSD17B10 | |
| SCHEMBL23968104 | 0.79 | CCNT1 (0.42) | MELKRET | |
| SCHEMBL23968094 | 0.78 | MELK (0.40) | MELKRETLRRK2 | |
| SCHEMBL23968098 | 0.77 | MELK (0.48) | MELKRET | |
| SCHEMBL23968162 | 0.74 | MELK (0.40) | MELKGAAMAPTHSD17B10 | |
| SCHEMBL23968008 | 0.71 | MELK (0.41) | MELKMAPT | |
| SCHEMBL23968179 | 0.71 | GRM4 (0.44) | MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3104705-B1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |