Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
| ▸ | ACP1 | P24666 | 1/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20856803 | 0.85 | CES2 (0.32) | MEN1KMT2APTPN1ACP1CDC25B | |
| SCHEMBL11026884 | 0.79 | CYP2C19 (0.38) | CYP2C19TSHR | |
| Hydrochloric Acid SCHEMBL11028858 | 0.77 | CYP2C19 (0.36) | CYP2C19TSHR | |
| SCHEMBL11526067 | 0.76 | CES2 (0.35) | MEN1KMT2APTPN1ACP1CDC25B | |
| SCHEMBL23642516 | 0.74 | ADORA3 (0.31) | MEN1KMT2ACYP2C19TSHR | |
| SCHEMBL20047451 | 0.73 | CES2 (0.38) | MEN1KMT2APTPN1TSHR | |
| SCHEMBL233232 | 0.71 | MEN1 (0.35) | MEN1KMT2A | |
| SCHEMBL13446458 | 0.71 | FFAR3 (0.38) | CYP2C19TSHR | |
| SCHEMBL9656053 | 0.69 | CYP2C19 (0.33) | MEN1KMT2ACYP2C19 | |
| SCHEMBL19307875 | 0.69 | SMPD1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | H. LUNDBECK A/S (DK) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | OPRL1, MGLL, VKORC1L1 | MEN1 1235/4885KMT2A 4106/4885CYP2C19 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.