Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19586554 | 0.85 | EPHX2 (0.49) | MGLLCYP2D6EPHX2ALDH1A1 | |
| SCHEMBL23642541 | 0.82 | OPRD1 (0.51) | OPRD1MGLLCYP2D6EPHX2ALDH1A1 | |
| SCHEMBL18711496 | 0.81 | CYP2D6 (0.58) | OPRD1OPRK1CYP2D6EPHX2ALDH1A1 | |
| SCHEMBL1556555 | 0.80 | EPHX2 (0.53) | MGLLCYP2D6EPHX2ALDH1A1 | |
| SCHEMBL19601951 | 0.79 | MGLL (0.60) | MGLL | |
| SCHEMBL18702131 | 0.78 | EPHX2 (0.48) | OPRD1MGLLCYP2D6EPHX2ALDH1A1 | |
| SCHEMBL25055762 | 0.78 | OPRD1 (0.49) | OPRD1OPRK1CYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL19582609 | 0.76 | MGLL (0.74) | MGLL | |
| SCHEMBL23642168 | 0.75 | CYP2D6 (0.65) | CYP2D6ALDH1A1 | |
| SCHEMBL1555874 | 0.75 | OPRD1 (0.49) | OPRD1OPRK1MGLLCYP2D6EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | H. LUNDBECK A/S (DK) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161856-B2 | Spirocycle compounds and methods of making and using same | OPRL1, MGLL, VKORC1L1 | OPRD1 80/4885OPRK1 13/4885MGLL 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.