Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19142861 | 0.89 | TAAR1 (0.37) | L3MBTL4L3MBTL3ALDH1A1TDP1SRC | |
| SCHEMBL25989384 | 0.83 | L3MBTL4 (0.38) | L3MBTL4L3MBTL3L3MBTL1SIGMAR1ALDH1A1 | |
| SCHEMBL5521760 | 0.81 | TYR (0.44) | L3MBTL1ALDH1A1TDP1SRCKDM4E | |
| SCHEMBL19295961 | 0.78 | KDM4E (0.41) | ALDH1A1TDP1SRCKDM4EHPGD | |
| SCHEMBL22176105 | 0.77 | SIGMAR1 (0.46) | L3MBTL4L3MBTL3L3MBTL1SIGMAR1ALDH1A1 | |
| SCHEMBL16953613 | 0.76 | SRC (0.39) | SIGMAR1ALDH1A1TDP1SRCKDM4E | |
| SCHEMBL24170215 | 0.76 | MPO (0.33) | L3MBTL1SMN1; SMN2MPOMEN1KMT2A | |
| SCHEMBL24244320 | 0.76 | TAAR1 (0.44) | L3MBTL4L3MBTL3L3MBTL1SIGMAR1ALDH1A1 | |
| SCHEMBL25996085 | 0.76 | TAAR1 (0.37) | L3MBTL4L3MBTL3ALDH1A1TDP1SRC | |
| SCHEMBL22176129 | 0.75 | L3MBTL4 (0.38) | L3MBTL4L3MBTL3L3MBTL1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |