Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | MPO | P05164 | 3/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23969379 | 0.93 | MPO (0.36) | SIGMAR1HTR2AMPOTAAR1RIPK1 | |
| SCHEMBL22176536 | 0.84 | RIPK1 (0.32) | MPOTAAR1RIPK1ACKR3 | |
| SCHEMBL22176388 | 0.82 | MPO (0.43) | SIGMAR1MPOTAAR1 | |
| SCHEMBL22175865 | 0.81 | MPO (0.42) | SIGMAR1MPOTAAR1 | |
| SCHEMBL22175911 | 0.80 | SLC6A4 (0.36) | SIGMAR1HTR2AMPO | |
| SCHEMBL22176371 | 0.79 | SIGMAR1 (0.36) | SIGMAR1KDM4E | |
| SCHEMBL22175889 | 0.76 | MAPT (0.39) | MPO | |
| SCHEMBL22176363 | 0.73 | MPO (0.46) | MPO | |
| SCHEMBL22176065 | 0.72 | HPGD (0.33) | MPOALDH1A1 | |
| SCHEMBL23969327 | 0.72 | IDO1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |