Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 2/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18689418 | 0.79 | POLQ (0.39) | POLQCTSDBACE1BACE2MAPT | |
| SCHEMBL7978950 | 0.62 | POLQ (0.47) | POLQCETPCTSDBACE1BACE2 | |
| SCHEMBL23969874 | 0.62 | TP53 (0.34) | MAPTTP53FAAHRXRARXRB | |
| SCHEMBL19425667 | 0.62 | LMNA (0.61) | MAPTTP53ALDH1A1HTTTDP1 | |
| SCHEMBL4163668 | 0.62 | POLQ (0.41) | POLQCTSDBACE1BACE2MAPT | |
| SCHEMBL23969932 | 0.61 | RXRA (0.34) | BACE1BACE2RXRARXRBRXRG | |
| SCHEMBL26186724 | 0.60 | TSHR (0.42) | CETPPNMTALDH1A1 | |
| SCHEMBL18689406 | 0.59 | SLC1A3 (0.54) | MAPTTP53ALDH1A1HTTTDP1 | |
| SCHEMBL11172699 | 0.56 | GRM5 (0.48) | DAOMAPTALDH1A1HTTTDP1 | |
| SCHEMBL13338397 | 0.56 | IDO1 (0.44) | CETPPNMTTP53ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353156-B1 | TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-11-03 | — | — | EP | disclosed |