Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 3/20 | 0.32 |
| ▸ | RXRB | P28702 | 3/20 | 0.32 |
| ▸ | RXRG | P48443 | 3/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23969932 | 0.94 | RXRA (0.34) | KDRTEKRXRARXRBRXRG | |
| SCHEMBL18688794 | 0.80 | MAPT (0.50) | TP53MAPTSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL23969881 | 0.75 | PPARG (0.31) | — | |
| SCHEMBL18689406 | 0.71 | SLC1A3 (0.54) | TP53MAPTSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL18689403 | 0.70 | MAPT (0.51) | TP53MAPT | |
| SCHEMBL20440877 | 0.68 | CYP1A2 (0.37) | MAPT | |
| SCHEMBL18689399 | 0.67 | MAPT (0.50) | TP53MAPT | |
| SCHEMBL18688798 | 0.64 | KMT2A (0.51) | TP53MAPT | |
| SCHEMBL31093906 | 0.63 | KIF11 (0.65) | RXRARXRBRXRGKIF11DHODH | |
| SCHEMBL23969852 | 0.62 | POLQ (0.33) | TP53MAPTFAAHRXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353156-B1 | TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-11-03 | — | — | EP | disclosed |