Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | QDPR | P09417 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11179661 | 0.94 | ALDH1A1 (0.48) | ALDH1A1ERN1LMNAMAPTCYP3A4 | |
| Hydrochloric Acid SCHEMBL11198973 | 0.92 | ALDH1A1 (0.46) | ALDH1A1ERN1LMNAMAPTCYP3A4 | |
| SCHEMBL183576 | 0.81 | — | — | |
| SCHEMBL23969869 | 0.80 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTLIMK1CNR1 | |
| SCHEMBL11194081 | 0.78 | CNR1 (0.50) | ALDH1A1ERN1LMNAMAPTHDAC1 | |
| SCHEMBL23969769 | 0.76 | ERN1 (0.50) | ALDH1A1ERN1CYP3A4CYP17A1CYP11B1 | |
| SCHEMBL19270240 | 0.76 | MAPT (0.73) | ERN1LMNAMAPTHDAC1HDAC6 | |
| SCHEMBL13907332 | 0.76 | MAPT (0.73) | ERN1LMNAMAPTHDAC1HDAC6 | |
| SCHEMBL13907285 | 0.76 | MAPT (0.73) | ERN1LMNAMAPTHDAC1HDAC6 | |
| SCHEMBL18748287 | 0.76 | MAPT (0.73) | ERN1LMNAMAPTHDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353156-B1 | TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-11-03 | — | — | EP | disclosed |