Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654544 | 0.87 | CNR1 (0.52) | ERN1MKNK1MKNK2MEN1PSIP1 | |
| SCHEMBL14425482 | 0.77 | CYP11B2 (0.66) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL14425488 | 0.77 | CYP11B2 (0.66) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL12103445 | 0.77 | CYP2A6 (0.79) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL30620885 | 0.77 | CYP2A6 (0.79) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL17951830 | 0.77 | CYP2A6 (0.79) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL23969858 | 0.76 | ALDH1A1 (0.43) | ERN1MEN1ALDH1A1CYP3A4CNR1 | |
| SCHEMBL17721072 | 0.76 | CYP11B2 (0.63) | MKNK1MKNK2MEN1PSIP1AXL | |
| SCHEMBL23969869 | 0.76 | ALDH1A1 (0.64) | ALDH1A1CNR1PGR | |
| SCHEMBL18134278 | 0.76 | CYP11B2 (0.63) | MKNK1MKNK2MEN1PSIP1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353156-B1 | TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-11-03 | — | — | EP | disclosed |