Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14418354 | 0.94 | ALDH1A1 (0.73) | ALDH1A1PTPN1PTPN11KDM4EMAPT | |
| SCHEMBL223423 | 0.94 | ALDH1A1 (0.73) | ALDH1A1PTPN1PTPN11KDM4EMAPT | |
| SCHEMBL14471626 | 0.89 | ALDH1A1 (0.60) | ALDH1A1PTPN1PTPN11KDM4EMAPT | |
| SCHEMBL23969765 | 0.87 | ALDH1A1 (0.48) | ALDH1A1PTPN1 | |
| SCHEMBL23969914 | 0.86 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL28254478 | 0.85 | ALDH1A1 (0.60) | ALDH1A1PTPN1PTPN11KDM4EMAPT | |
| SCHEMBL27895559 | 0.80 | ALDH1A1 (0.65) | ALDH1A1MMP8MMP14CA14LIMK1 | |
| SCHEMBL23969858 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MAPTLMNALIMK1CNR1 | |
| Formanilide SCHEMBL29177030 | 0.79 | ALDH1A1 (1.00) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23353504 | 0.79 | ALDH1A1 (1.00) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353156-B1 | TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2021-11-03 | — | — | EP | disclosed |