Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 3/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.31 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.31 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21705262 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL19098322 | 0.82 | GBA1 (0.40) | SMN1; SMN2GBA1SI | |
| SCHEMBL25501186 | 0.78 | GBA1 (0.46) | SMN1; SMN2GBA1 | |
| SCHEMBL23475112 | 0.78 | GBA1 (0.46) | SMN1; SMN2GBA1 | |
| SCHEMBL13286238 | 0.78 | GBA1 (0.38) | SMN1; SMN2GBA1 | |
| SCHEMBL27424183 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2GBA1GNAI3GNAO1GNAI1 | |
| SCHEMBL24571398 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2GBA1GNAI3GNAO1GNAI1 | |
| SCHEMBL29255397 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2GBA1GNAI3GNAO1GNAI1 | |
| SCHEMBL14071752 | 0.74 | GBA1 (0.38) | SMN1; SMN2GBA1 | |
| SCHEMBL13286237 | 0.74 | GBA1 (0.38) | SMN1; SMN2GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |