Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28609423 | 0.79 | TLR8 (0.54) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL19260213 | 0.79 | TDP1 (0.52) | TLR8ALDH1A1HPGDGLAMAPT | |
| Ammonia Solution, Strong SCHEMBL9131397 | 0.77 | TLR8 (0.53) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL27851831 | 0.75 | KDM4E (0.54) | ALDH1A1HPGDMAPTLCKKDM4E | |
| SCHEMBL12388168 | 0.74 | ALDH1A1 (0.55) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL12410896 | 0.74 | ALDH1A1 (0.48) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL13949449 | 0.73 | ALOX15 (0.42) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL2630610 | 0.73 | TLR8 (0.46) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL14726026 | 0.73 | HPGD (0.48) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL22045308 | 0.73 | TLR8 (0.57) | TLR8ALDH1A1HPGDGLAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |