Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 1.00 |
| ▸ | PDE4A | P27815 | 8/20 | 0.79 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.79 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.79 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.79 |
| ▸ | PDE2A | O00408 | 2/20 | 0.79 |
| ▸ | PDE1A | P54750 | 2/20 | 0.79 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.79 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.79 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | PDE5A | O76074 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 1/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | SCN1A | P35498 | 1/20 | 0.79 |
| ▸ | PDE6C | P51160 | 1/20 | 0.79 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.79 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.79 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isobutylmethylxanthine SCHEMBL4262798 | 0.90 | PDE4A (0.92) | CFTRPDE4APDE4BPDE4CPDE4D | |
| Isobutylmethylxanthine SCHEMBL50315 | 0.88 | PDE4A (1.00) | CFTRPDE4APDE4BPDE4CPDE4D | |
| Isobutylmethylxanthine SCHEMBL28814716 | 0.88 | PDE4A (1.00) | CFTRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28468033 | 0.87 | CFTR (0.77) | CFTRPDE4APDE4BPDE4CPDE4D | |
| Isobutylmethylxanthine SCHEMBL7637581 | 0.86 | PDE4A (0.94) | CFTRPDE4APDE4BPDE4CPDE4D | |
| Isobutylmethylxanthine SCHEMBL3185038 | 0.86 | PDE4A (0.83) | CFTRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27598085 | 0.85 | PDE4A (0.75) | CFTRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27324979 | 0.83 | CFTR (0.71) | CFTRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7016029 | 0.83 | ADORA2A (1.00) | CFTRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9430480 | 0.83 | CFTR (0.71) | CFTRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669973-A1 | BIOLOGICAL FACTORS AND NEURAL STEM CELLS | NEUROSPHERES HOLDINGS LTD. (CA) | 1995-09-06 | — | — | EP | claimed |
| WO-1994010292-A1 | BIOLOGICAL FACTORS AND NEURAL STEM CELLS | NEUROSPHERES LTD. (CA) | 1994-05-11 | — | — | WO | claimed |
| EP-4747374-A2 | ANTISENSE OLIGONUCLEOTIDES AND ARTIFICIAL EXPRESSION CONSTRUCTS FOR EXPRESSING RNA IN INHIBITORY NEURONS | Allen Institute (US) | 2026-05-27 | — | — | EP | disclosed |
| WO-2026102237-A1 | ARTIFICIAL EXPRESSION CONSTRUCTS FOR MODULATING GENE EXPRESSION IN ASTROCYTES FOR THE ASSESSMENT AND/OR TREATMENT OF EPILEPTIC DISORDERS | Allen Institute (US) | 2026-05-15 | — | — | WO | disclosed |
| US-20260071160-A1 | SCALABLE BIOREACTOR SYSTEMS AND METHODS FOR TISSUE ENGINEERING | FairCraft SAS (FR) | 2026-03-12 | — | — | US | disclosed |
| EP-4689077-A2 | CONDITIONALLY IMMORTALIZED STEM CELLS AND USES THEREOF | Pluristyx, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-12467064-B2 | Artificial expression constructs for selectively modulating gene expression in interneurons | Allen Institute (US) | 2025-11-11 | — | — | US | disclosed |
| US-20250235550-A1 | ARTIFICIAL EXPRESSION CONSTRUCTS FOR MODULATING GENE EXPRESSION IN THE CEREBELLUM AND A SECONDARY CELL TYPE | Allen Institute (US) | 2025-07-24 | — | — | US | disclosed |
| US-20250236886-A1 | ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN EXCITATORY CORTICAL NEURONS | Allen Institute (US) | 2025-07-24 | — | — | US | disclosed |
| US-20250223612-A1 | ARTIFICIAL EXPRESSION CONSTRUCTS FOR SELECTIVELY MODULATING GENE EXPRESSION IN INTERNEURONS | Allen Institute (US) | 2025-07-10 | — | — | US | disclosed |
| US-20250188421-A1 | METHODS OF MAKING INDUCED PLURIPOTENT STEM CELLS | PLURISTYX, INC. (US) | 2025-06-12 | — | — | US | disclosed |
| US-5851832-A | In vitro growth and proliferation of multipotent neural stem cells and their progeny | NEUROSPHERES, LTD. (CA) | 1998-12-22 | — | — | US | disclosed |
| WO-1998022127-A9 | PRETREATMENT WITH GROWTH FACTORS TO PROTECT AGAINST CNS DAMAGE | — | 1998-09-11 | — | — | WO | disclosed |
| WO-1998022127-A1 | PRETREATMENT WITH GROWTH FACTORS TO PROTECT AGAINST CNS DAMAGE | NEUROSPHERES HOLDINGS LTD. (CA) | 1998-05-28 | — | — | WO | disclosed |
| US-5750376-A | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny | NEUROSPHERES HOLDINGS LTD. (CA) | 1998-05-12 | — | — | US | disclosed |
| EP-0669973-A1 | BIOLOGICAL FACTORS AND NEURAL STEM CELLS | NEUROSPHERES HOLDINGS LTD. (CA) | 1995-09-06 | — | — | EP | disclosed |
| WO-1994010292-A1 | BIOLOGICAL FACTORS AND NEURAL STEM CELLS | NEUROSPHERES LTD. (CA) | 1994-05-11 | — | — | WO | disclosed |
| US-5196315-A | HUMAN NEURONAL CELL LINE | THE JOHNS HOPKINS UNIVERSITY (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0528954-A1 | HUMAN NEURONAL CELL LINE | THE JOHNS HOPKINS UNIVERSITY (US) | 1993-03-03 | — | — | EP | disclosed |
| WO-1991017242-A1 | HUMAN NEURONAL CELL LINE | THE JOHNS HOPKINS UNIVERSITY (US) | 1991-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260071160-A1 | SCALABLE BIOREACTOR SYSTEMS AND METHODS FOR TISSUE ENGINEERING | FGF2, FGF23, FIBP | CFTR 2192/4885PDE4A 1588/4885PDE4B 2150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.