Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 8/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CLPP | Q16740 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23973188 | 0.93 | CLPP (0.44) | MTHFD2KDROPRD1ROCK2CLPP | |
| SCHEMBL23973473 | 0.92 | MTHFD2 (0.42) | MTHFD2KDRROCK2CLPP | |
| SCHEMBL23972409 | 0.92 | TRPV1 (0.48) | MTHFD2KDRROCK2CLPP | |
| SCHEMBL23972215 | 0.91 | CLPP (0.47) | MTHFD2KDROPRD1KMT2AMEN1 | |
| SCHEMBL26672609 | 0.91 | MTHFD2 (0.41) | MTHFD2KDRROCK2 | |
| SCHEMBL23973478 | 0.91 | ROCK2 (0.43) | MTHFD2KDROPRD1ROCK2 | |
| SCHEMBL23972655 | 0.91 | AURKA (0.42) | MTHFD2KDRROCK2CLPP | |
| SCHEMBL23972465 | 0.91 | CLPP (0.46) | MTHFD2KDRROCK2CLPP | |
| SCHEMBL26672604 | 0.91 | CLPP (0.45) | MTHFD2KDRCLPPKCNK3 | |
| SCHEMBL23972407 | 0.89 | MEN1 (0.46) | MTHFD2KMT2AMEN1CLPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021221169-A1 | PYRIMIDIN-4(3H)-ONE DERIVATIVES AS TRPV4 ANTAGONISTS | RAQUALIA PHARMA INC. (JP) | 2021-11-04 | — | — | WO | disclosed |