Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975119 | 0.72 | POLB (0.70) | POLBSMN1; SMN2GFERHSD11B1KMT2A | |
| SCHEMBL22691653 | 0.70 | GFER (0.76) | POLBGFERKMT2AHTR7ALDH1A1 | |
| SCHEMBL30103768 | 0.69 | ESR1 (0.61) | POLBSMN1; SMN2GFERHSD11B1MAPT | |
| SCHEMBL22691615 | 0.69 | GFER (0.56) | POLBGFERKMT2AMEN1MAPT | |
| SCHEMBL31409153 | 0.66 | GFER (0.50) | GFERKMT2AMEN1MAPTHTR7 | |
| SCHEMBL28659025 | 0.66 | ESR1 (0.69) | POLBSMN1; SMN2HSD11B1KMT2AMEN1 | |
| SCHEMBL28648417 | 0.65 | ESR1 (0.74) | POLBSMN1; SMN2HSD11B1KMT2AMEN1 | |
| SCHEMBL22691883 | 0.64 | GFER (0.64) | POLBGFERKMT2AMAPTHTR7 | |
| SCHEMBL22691888 | 0.63 | GFER (0.47) | POLBGFERHSD11B1KMT2AMEN1 | |
| SCHEMBL22691868 | 0.63 | GFER (0.50) | POLBGFERHSD11B1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210338680-A1 | METHODS RELATED TO OPIOID THERAPEUTICS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338680-A1 | METHODS RELATED TO OPIOID THERAPEUTICS | OPRL1, OPRK1, GPR139 | POLB 4642/4885SMN1; SMN2 2889/4885GFER 2415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.