Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24702476 | 0.79 | CHRNB2 (0.39) | CHRNB2CHRNB4CHRNA4CHRNA2PDE10A | |
| SCHEMBL29084846 | 0.78 | MEN1 (0.59) | CHRNB2CHRNB4CHRNA4CHRNA2MEN1 | |
| SCHEMBL30585079 | 0.78 | MEN1 (0.59) | CHRNB2CHRNB4CHRNA4CHRNA2MEN1 | |
| SCHEMBL7923072 | 0.77 | NPC1 (0.39) | PDE10AMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL6030154 | 0.76 | NOTUM (0.43) | CHRNB2CHRNB4CHRNA4CHRNA2RIPK1 | |
| SCHEMBL16692755 | 0.76 | CYP2C19 (0.35) | CHRNB2CHRNB4CHRNA4CHRNA2CYP2C19 | |
| SCHEMBL25044274 | 0.75 | GRM5 (0.36) | PDE10AMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL13094745 | 0.75 | MAOA (0.57) | CHRNB2CHRNB4CHRNA4CHRNA2PDE10A | |
| SCHEMBL20262350 | 0.73 | CYP11B2 (0.42) | CYP3A4RIPK1 | |
| SCHEMBL22583106 | 0.72 | GRM5 (0.37) | SMN1; SMN2KDM4EALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |