Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | DRD1 | P21728 | 1/20 | 0.62 |
| ▸ | DRD5 | P21918 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26268651 | 0.88 | ABHD6 (0.52) | DRD2DRD3DRD1DRD5ABHD6 | |
| SCHEMBL24317348 | 0.88 | DRD2 (0.56) | DRD2DRD3DRD1DRD5ABHD6 | |
| SCHEMBL23976082 | 0.86 | DRD1 (0.76) | DRD2DRD3DRD1DRD5HDAC1 | |
| SCHEMBL25943620 | 0.83 | DRD2 (0.58) | DRD2DRD3DRD1DRD5HDAC1 | |
| SCHEMBL24702129 | 0.80 | DRD2 (0.55) | DRD2DRD3DRD1DRD5HDAC1 | |
| SCHEMBL24702156 | 0.80 | DRD2 (0.55) | DRD2DRD3DRD1DRD5HDAC1 | |
| SCHEMBL11736393 | 0.79 | DRD1 (0.67) | DRD2DRD3DRD1DRD5ABHD6 | |
| SCHEMBL5568684 | 0.79 | DRD1 (0.77) | DRD2DRD3DRD1DRD5ADRA2A | |
| SCHEMBL19133719 | 0.79 | DRD2 (0.58) | DRD2DRD3DRD1DRD5CHRM2 | |
| Ammonia Solution, Strong SCHEMBL7667257 | 0.77 | DRD2 (0.56) | DRD2DRD3DRD1DRD5CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |