Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24702095 | 0.92 | LMNA (0.38) | PDE10AMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL25926506 | 0.85 | PDE10A (0.42) | PDE10AMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL23975710 | 0.82 | PDE10A (0.40) | PDE10AMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL30118843 | 0.82 | PDE10A (0.40) | PDE10AMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL23975783 | 0.81 | PDE10A (0.40) | PDE10AMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL23975698 | 0.77 | PDE10A (0.37) | PDE10AMEN1KMT2ARAB9ACFTR | |
| SCHEMBL23975829 | 0.77 | MAPT (0.33) | — | |
| SCHEMBL23976578 | 0.77 | MEN1 (0.41) | PDE10AMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL30118586 | 0.77 | MEN1 (0.41) | PDE10AMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL23975799 | 0.76 | PDE10A (0.36) | PDE10AMEN1KMT2ARAB9ACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |