Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675047 | 0.88 | ADRB1 (0.71) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL3051915 | 0.85 | ADRB1 (0.71) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL30255158 | 0.85 | ADRB1 (0.71) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL11074672 | 0.85 | ADRB1 (0.76) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL30180110 | 0.83 | ADRB1 (0.69) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL3035322 | 0.83 | ADRB1 (0.69) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL23657330 | 0.83 | KCNH2 (0.61) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL19212406 | 0.80 | ADRB1 (0.69) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL25917171 | 0.79 | ADRB1 (0.55) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL25923493 | 0.79 | DRD2 (0.69) | ADRB1MAPTNPC1KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |