Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | QSOX1 | O00391 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30180110 | 1.00 | ADRB1 (0.69) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL3051915 | 0.98 | ADRB1 (0.71) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL30255158 | 0.98 | ADRB1 (0.71) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL23675047 | 0.94 | ADRB1 (0.71) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL11074672 | 0.90 | ADRB1 (0.76) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL2277657 | 0.85 | ADRB1 (0.56) | ADRB1MAPTNPC1KCNH2DRD2 | |
| Anisole SCHEMBL27764388 | 0.85 | ALDH1A1 (0.54) | ADRB1MAPTMEN1CYP3A4KMT2A | |
| SCHEMBL19212406 | 0.85 | ADRB1 (0.69) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL23657330 | 0.84 | KCNH2 (0.61) | ADRB1MAPTNPC1KCNH2DRD2 | |
| SCHEMBL23975996 | 0.83 | ADRB1 (0.58) | ADRB1MAPTNPC1KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396316-B1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-01 | — | — | EP | claimed |
| US-8937078-B2 | Quinazolinones as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-20 | — | — | US | claimed |
| EP-2396316-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2011-12-21 | — | — | EP | claimed |
| WO-2010093727-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-19 | — | — | WO | claimed |
| US-20100204226-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-12 | — | — | US | claimed |
| US-6596724-B2 | Used in promoting weight loss and treating eating disorders | BRISTOL-MYERS SQUIBB COMPANY | 2003-07-22 | — | — | US | claimed |
| US-6391881-B2 | ANOREXOGENIC AGENTS TO PROMOTE WEIGHT LOSS AND TREAT EATING DISORDERS | BRISTOL-MYERS SQUIBB COMPANY | 2002-05-21 | — | — | US | claimed |
| US-20020013323-A1 | Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2002-01-31 | — | — | US | claimed |
| WO-2001089528-A1 | THIOUREA DERIVATIVES OF DIHYDROPYRIDINE NPY ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-11-29 | — | — | WO | claimed |
| US-20010047003-A1 | Anorexogenic agents to promote weight loss and treat eating disorders | SIT SING-YUEN (US) | 2001-11-29 | — | — | US | claimed |
| US-11492359-B2 | Near-infrared nerve-sparing fluorophores | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2022-11-08 | — | — | US | disclosed |
| US-20210317137-A1 | NEAR-INFRARED NERVE-SPARING FLUOROPHORES | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-10-14 | — | — | US | disclosed |
| US-20210317137-A1 | NEAR-INFRARED NERVE-SPARING FLUOROPHORES | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-10-14 | — | — | US | disclosed |
| US-20210236657-A1 | NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-20210236657-A1 | NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-4209618-A | COLOR PRECURSORS IN PRESSURE-SENSITIVE DUPLICATING SYSTEMS AND HEAT-SENSITIVE MARKING SYSTEMS | STERLING DRUG INC. (US) | 1980-06-24 | — | — | US | disclosed |
| US-4200751-A | COLOR-FORMING AGENTS | YAMAMOTO KAGAKU GOSEI CO., LTD. (JP) | 1980-04-29 | — | — | US | disclosed |
| US-4096176-A | Benzoylbenzoic acids | STERLING DRUG INC. (US) | 1978-06-20 | — | — | US | disclosed |
| US-4094877-A | SUBSTITUTED 3,3-DIPHENYLPHTHALIDES AS COLOR PRECURSORS | STERLING DRUG INC. (US) | 1978-06-13 | — | — | US | disclosed |
| US-4032527-A | COLOR PRECURSORS | STERLING DRUG INC. (US) | 1977-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492359-B2 | Near-infrared nerve-sparing fluorophores | NTRK1, PMP22, GAP43 | ADRB1 706/4885MAPT 636/4885NPC1 3548/4885 |
| US-20210236657-A1 | NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION | PFAS, NPFFR2, NPFFR1 | ADRB1 2211/4885MAPT 1093/4885NPC1 1620/4885 |
| US-20100204226-A1 | QUINAZOLINONES AS PROLYL HYDROXYLASE INHIBITORS | P4HA1, EGLN3, EGLN2 | ADRB1 2413/4885MAPT 4308/4885NPC1 2457/4885 |
| US-20210317137-A1 | NEAR-INFRARED NERVE-SPARING FLUOROPHORES | NTRK1, NGF, SMN1; SMN2 | ADRB1 1287/4885MAPT 803/4885NPC1 2076/4885 |
| US-20020013323-A1 | Oxadiazole and thiadiazole derivatives of dihydropyridine NPY antagonists | NPY1R, NPY2R, NPY5R | ADRB1 133/4885MAPT 3991/4885NPC1 4659/4885 |
| US-20010047003-A1 | Anorexogenic agents to promote weight loss and treat eating disorders | NPY1R, NPY2R, NPY5R | ADRB1 159/4885MAPT 4424/4885NPC1 2625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.