Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23976238 | 0.92 | SPR (0.40) | SPRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL30225199 | 0.92 | SPR (0.40) | SPRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL23975733 | 0.88 | MAPT (0.38) | SPRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL30225287 | 0.88 | MAPT (0.38) | SPRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL23975583 | 0.88 | TUBB3 (0.39) | SPRALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL23976223 | 0.87 | HDAC1 (0.37) | SPRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL23976647 | 0.86 | GAA (0.41) | SPRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL23975788 | 0.85 | KMT2A (0.45) | ALDH1A1KMT2AMEN1POLBLMNA | |
| SCHEMBL23975765 | 0.84 | GAA (0.41) | SPRALDH1A1MAPTKMT2AHTT | |
| SCHEMBL23975819 | 0.84 | HDAC1 (0.35) | SPRALDH1A1MAPTKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |