Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12939844 | 0.89 | KDM2B (0.40) | LTA4HKDM2B | |
| SCHEMBL24443851 | 0.89 | ESR1 (0.38) | GRIN1GRIN2BESR1 | |
| SCHEMBL9969576 | 0.89 | KDM2B (0.40) | LTA4HKDM2B | |
| SCHEMBL16065870 | 0.88 | LMNA (0.35) | LTA4HAOC3 | |
| SCHEMBL25365601 | 0.84 | ALOX15 (0.41) | GRIN1GRIN2BLTA4HGRM2BACE1 | |
| SCHEMBL6827945 | 0.84 | ALOX15 (0.41) | GRIN1GRIN2BLTA4HGRM2BACE1 | |
| SCHEMBL25363068 | 0.84 | ALOX15 (0.41) | GRIN1GRIN2BLTA4HGRM2BACE1 | |
| SCHEMBL15685442 | 0.82 | DRD2 (0.41) | — | |
| SCHEMBL15133969 | 0.82 | DRD2 (0.41) | — | |
| SCHEMBL10152381 | 0.82 | DRD2 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2021222363-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |