Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.44 |
| ▸ | METAP1 | P53582 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975837 | 0.86 | KDM4E (0.45) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL23991552 | 0.85 | KDM4E (0.46) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL23975886 | 0.85 | KDM4E (0.48) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL23976260 | 0.85 | KDM4E (0.46) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL23975855 | 0.84 | ALDH1A1 (0.44) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL23976691 | 0.81 | KDM4E (0.41) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL23975881 | 0.81 | LMNA (0.45) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL23976553 | 0.78 | ALDH1A1 (0.43) | METAP2METAP1KDM4EMEN1KMT2A | |
| SCHEMBL25934447 | 0.78 | KDM4E (0.40) | METAP2METAP1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL5120516 | 0.77 | SMN1; SMN2 (0.54) | METAP2METAP1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |